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Accepted: Published: Version of record: Issue date: DOI:

Acta Physiol Plant 21:175188

B12 injection (hydroxocobalamin or cyanocobalamin): The injection completely bypasses the digestive system and sends the vitamin directly into the muscles and blood for immediate use

Active cancer or history of malignancy Pregnancy or breastfeeding Known peptide allergies Athletes subject to anti-doping testing (WADA prohibited) Raynauds disease or phenomenon Cold urticaria (hives from cold) Uncontrolled hypertension Peripheral vascular disease Open wounds (for local application) Pregnancy Cardiovascular conditions Diabetes (especially with neuropathy) Current infections Immunosuppression Blood clotting disorders Quality control issues represent perhaps the greatest practical risk with BPC-157